Neuropeptide‐Y Levels in ST‐Segment–Elevation Myocardial Infarction: Relationship With Coronary Microvascular Function, Heart Failure, and Mortality. Gibbs T, Tapoulal N, Shanmuganathan M, Burrage MK, Borlotti A, Banning AP, Choudhury RP, Neubauer S, Kharbanda RK, Ferreira VM, Channon KM, Herring N and OxAMI Study. Originally published 29 Jun 2022 https://doi.org/10.1161/JAHA.121.024850. Journal of the American Heart Association. 2022;11:e024850
Neutrophils incite and macrophages avert electrical storm after myocardial infarction Grune J, Lewis AJM, Yamazoe M et al. Nat Cardiovasc Res (2022). https://doi.org/10.1038/s44161-022-00094-w
Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles. Akbar N, Braithwaite AT, Corr EM, Koelwyn GJ, van Solingen C, Cochain C, Saliba AE, Corbin A, Pezzolla D, Møller Jørgensen M, Bæk R, Edgar L, De Villiers C, Gunadasa-Rohling M, Banerjee A, Paget D, Lee C, Hogg E, Costin A, Dhaliwal R, Johnson E, Krausgruber T, Riepsaame J, Melling GE, Shanmuganathan M; Oxford Acute Myocardial Infarction Study (OxAMI), Bock C, Carter DRF, Channon KM, Riley PR, Udalova IA, Moore KJ, Anthony D, Choudhury RP.Cardiovasc Res. 2022 Feb 4:cvac012. doi: 10.1093/cvr/cvac012. Online ahead of print.PMID: 35134856
Long-term prognosis after acute ST-segment elevation myocardial infarction is determined by characteristics in both non-infarcted and infarcted myocardium on cardiovascular magnetic resonance imaging. Shanmuganathan M, Masi A, Burrage MK, et al. Heart 2021;107:A1
A CMR first strategy in patients with suspected NSTEMI may help identify MINOCA and infarct related artery. Shanmuganathan M, Borlotti A, Scarsini R, Nikolaidou C, Gara E, Burrage M, Ferreira V (2021). European Heart Journal — Cardiovascular Imaging Vol. 22.
Pre-procedural ATI score (age-thrombus burden-index of microcirculatory resistance) predicts long-term clinical outcomes in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention. Montalto C, Kotronias RA, Marin F, Terentes-Printzios D, Shanmuganathan M, Emfietzoglou M, Scalamera R, Porto I, Langrish J, Lucking A, Choudhury R, Kharbanda R, Channon KM, De Maria GL, Banning A; Oxford Acute Myocardial Infarction (OxAMI) Study. Int J Cardiol. 2021 Sep 15;339:1-6. doi: 10.1016/j.ijcard.2021.07.040. Epub 2021 Jul 23. PMID: 34311009.
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. He W, McCarroll CS, Nather K, Ford K, Mangion K, Riddell A, O’Toole D, Zaeri A, Corcoran D, Carrick D, Lee MMY, McEntegart M, Davie A, Good R, Lindsay MM, Eteiba H, Rocchiccioli P, Watkins S, Hood S, Shaukat A, McArthur L, Elliott EB, McClure J, Hawksby C, Martin T, Petrie MC, Oldroyd KG, Smith GL; Oxford Acute Myocardial Infarction (OxAMI) Study, Channon KM, Berry C, Nicklin SA, Loughrey CM. Cardiovasc Res. 2021 Jun 16:cvab204. doi: 10.1093/cvr/cvab204. Epub ahead of print. PMID: 34132807.
Pressure-controlled intermittent coronary sinus occlusion improves the vasodilatory microvascular capacity and reduces myocardial injury in patients with STEMI. Scarsini R, Terentes-Printzios D, Shanmuganathan M, Kotronias RA, Borlotti A, Marin F, Langrish J, Lucking A, Ribichini F; Oxford Acute Myocardial Infarction (OxAMI) Study, Kharbanda R, Ferreira VM, Channon KM, De Maria GL, Banning AP. Catheter Cardiovasc Interv. 2021 May 29. doi: 10.1002/ccd.29793. Epub ahead of print. PMID: 34051133.
Angiography-derived index of microcirculatory resistance (IMRangio) as a novel pressure-wire- free tool to assess coronary microvascular dysfunction in acute coronary syndromes and stable coronary artery disease. Scarsini R, Shanmuganathan M, Kotronias RA, Terentes-Printzios D, Borlotti A, Langrish JP, Lucking AJ; OxAMI Study Investigators, Ribichini F, Ferreira VM, Channon KM, Garcia-Garcia HM, Banning AP, De Maria GL. Int J Cardiovasc Imaging. 2021 Jun;37(6):1801-1813. doi: 10.1007/s10554-021-02254-8. Epub 2021 May 5. PMID: 33950329.
Coronary Microvascular Dysfunction Assessed by Pressure Wire and CMR After STEMI Predicts Long-Term Outcomes. Scarsini R, Shanmuganathan M, De Maria GL, Borlotti A, Kotronias RA, Burrage MK, Terentes-Printzios D, Langrish J, Lucking A, Fahrni G, Cuculi F, Ribichini F, Choudhury RP, Kharbanda R, Ferreira VM, Channon KM, Banning AP; OxAMI Study Investigators. JACC Cardiovasc Imaging. 2021 Oct;14(10):1948-1959. doi: 10.1016/j.jcmg.2021.02.023. Epub 2021 Apr 14. PMID: 33865789.
Angiography-derived index of microcirculatory resistance as a novel, pressure-wire-free tool to assess coronary microcirculation in ST elevation myocardial infarction. De Maria GL, Scarsini R, Shanmuganathan M, Kotronias RA, Terentes-Printzios D, Borlotti A, Langrish JP, Lucking AJ, Choudhury RP, Kharbanda R, Ferreira VM; Oxford Acute Myocardial Infarction (OXAMI) Study Investigators, Channon KM, Garcia-Garcia HM, Banning AP. Int J Cardiovasc Imaging. 2020 Aug;36(8):1395-1406. doi: 10.1007/s10554-020-01831-7. Epub 2020 May 14. PMID: 32409977; PMCID: PMC7381481.
Reflectance spectral analysis for novel characterization and clinical assessment of aspirated coronary thrombi in patients with ST elevation myocardial infarction. De Maria GL, Lee R, Alkhalil M, Borlotti A, Kotronias R, Langrish J, Lucking A, Dawkins S, Choudhury RP, Kharbanda R, Banning AP, Vallance C, Channon KM. Physiol Meas. 2020 May 7;41(4):045001. doi: 10.1088/1361-6579/ab81de. PMID: 32197256.
Hyper-acute cardiovascular magnetic resonance T1 mapping predicts infarct characteristics in patients with ST elevation myocardial infarction. Alkhalil M, Borlotti A, De Maria GL, Wolfrum M, Dawkins S, Fahrni G, Gaughran L; Oxford Acute Myocardial Infarction (OxAMI) Study, Langrish JP, Lucking A, Ferreira VM, Kharbanda RK, Banning AP, Dall’Armellina E, Channon KM, Choudhury RP. J Cardiovasc Magn Reson. 2020 Jan 9;22(1):3. doi: 10.1186/s12968-019-0593-9. PMID: 31915031; PMCID: PMC6951001.
Pressure-bounded coronary flow reserve to assess the extent of microvascular dysfunction in patients with ST-elevation acute myocardial infarction. Scarsini R, De Maria GL, Shanmuganathan M, Kotronias RA, Terentes-Printzios D, Langrish J, Lucking AJ, Ribichini FL, Choudhury R, Kharbanda RK, Ferreira V, Channon KM, Banning AP; Collaborators. EuroIntervention. 2021 Apr 20;16(17):1434-1443. doi: 10.4244/EIJ-D-19-00674. PMID: 31854300.
The cardiac sympathetic co-transmitter neuropeptide Y is pro- arrhythmic following ST-elevation myocardial infarction despite beta-blockade. Kalla M, Hao G, Tapoulal N, Tomek J, Liu K, Woodward L; ‘Oxford Acute Myocardial Infarction (OxAMI) Study’, Dall’Armellina E, Banning AP, Choudhury RP, Neubauer S, Kharbanda RK, Channon KM, Ajijola OA, Shivkumar K, Paterson DJ, Herring N. Eur Heart J. 2020 Jun 14;41(23):2168-2179. doi: 10.1093/eurheartj/ehz852. PMID: 31834357; PMCID: PMC7299634.
Neuropeptide-Y causes coronary microvascular constriction and is associated with reduced ejection fraction following ST-elevation myocardial infarction. Herring N et al. Eur Heart J. 2019 Mar 11.
Incremental value of coronary microcirculation resistive reserve ratio in predicting the extent of myocardial infarction in patients with STEMI. Insights from the Oxford Acute Myocardial Infarction (OxAMI) study. Scarsini R et al. Cardiovasc Revasc Med. 2019 Feb 16.
Combined T1-mapping and tissue tracking analysis predicts severity of ischemic injury following acute STEMI-an Oxford Acute Myocardial Infarction (OxAMI) study. Wamil M et al. Int J Cardiovasc Imaging. 2019 Feb 16.
Acute Microvascular Impairment Post-Reperfused STEMI Is Reversible and Has Additional Clinical Predictive Value: A CMR OxAMI Study. Borlotti A et al. JACC Cardiovasc Imaging. 2019 Jan 9.
Dynamic changes in injured myocardium, very early after acute myocardial infarction, quantified using T1 mapping cardiovascular magnetic resonance. Alkhalil M et al. J Cardiovasc Magn Reson. 2018 Dec 20;20(1):82.
Index of microcirculatory resistance-guided therapy with pressure-controlled intermittent coronary sinus occlusion improves coronary microvascular function and reduces infarct size in patients with ST-elevation myocardial infarction: the Oxford Acute Myocardial Infarction – Pressure-controlled Intermittent Coronary Sinus Occlusion study (OxAMI-PICSO study). De Maria GL et al. EuroIntervention. 2018 Jun 8;14(3):352-359.
Index of Microcirculatory Resistance as a Tool to Characterize Microvascular Obstruction and to Predict Infarct Size Regression in Patients With STEMI Undergoing Primary PCI. De Maria GL et al. JACC Cardiovasc Imaging. 2018 Apr 14.
Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury. Kohlhauer M et al. J Am Heart Assoc. 2018 Apr 6;7(8).
Hyperaemic microvascular resistance predicts clinical outcome and microvascular injury after myocardial infarction. de Waard GA et al. Heart. 2018 Jan;104(2):127-134.
Index of Microcirculatory Resistance at the Time of Primary Percutaneous Coronary Intervention Predicts Early Cardiac Complications: Insights From the OxAMI (Oxford Study in Acute Myocardial Infarction) Cohort. Fahrni G et al. J Am Heart Assoc. 2017 Nov 7;6(11).
The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: a cardiac magnetic resonance validation study. De Maria GL et al. EuroIntervention. 2017 Oct 20;13(8):935-943.
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction. Akbar N, et al. JCI Insight. 2017 Sep 7;2(17).
CMR Native T1 Mapping Allows Differentiation of Reversible Versus Irreversible Myocardial Damage in ST-Segment-Elevation Myocardial Infarction: An OxAMI Study (Oxford Acute Myocardial Infarction).
Liu D, et al. Circ Cardiovasc Imaging. 2017 Aug;10(8).
The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST elevation infarction. De Maria GL, et al. Coron Artery Dis. 2016 Dec 6.
A tool for predicting the outcome of reperfusion in ST elevation myocardial infarction using Age, Thrombotic burden and index of microcirculatory resistance (ATI score). De Maria GL, et al. Eurointervention. 2016 Nov 20;12(10):1223-1230.
Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans. Ruparelia N, et al. Eur Heart J. 2015 Aug 1;36(29):1923-34.
Zero-Flow Pressure Measured Immediately After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Provides the Best Invasive Index for Predicting the Extent of Myocardial Infarction at 6 Months: An OxAMI Study (Oxford Acute Myocardial Infarction). Patel N, et al. JACC Cardiovasc Interv. 2015 Sep;8(11):1410-21.
How does coronary stent implantation impact on the status of the microcirculation during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction? De Maria GL, et al. Eur Heart J. 2015 Dec 1;36(45):3165-77.
Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction. Cuculi F, et al. J Am Coll Cardiol. 2014 Nov 4;64(18):1894-904.
Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction. Cuculi F, et al. Eur Heart J. 2014 Aug 1;35(29):1971-80.
Relationship of plasma neuropeptide Y with angiographic, electrocardiographic and coronary physiology indices of reperfusion during ST elevation myocardial infarction. Cuculi F, et al. Heart. 2013 Aug;99(16):1198-203.